GDP-mannose 4,6-dehydratase
Symbol
GMDS
(may also be known as: None)
Organism
Human
Description
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| gmd-2 | Caenorhabditis elegans | |
| Gmd | Drosophila melanogaster | |
| gmds | Danio rerio | |
| Gmds | Mus musculus | |
| Gmds | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007219 | Notch signaling pathway | biological_process | |
| GO:0019673 | GDP-mannose metabolic process | biological_process | |
| GO:0042351 | 'de novo' GDP-L-fucose biosynthetic process | biological_process | |
| GO:0044237 | cellular metabolic process | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003824 | catalytic activity | molecular_function | |
| GO:0008446 | GDP-mannose 4,6-dehydratase activity | molecular_function | |
| GO:0016829 | lyase activity | molecular_function | |
| GO:0050662 | coenzyme binding | molecular_function | |
| GO:0070401 | NADP+ binding | molecular_function | |