basic helix-loop-helix family, member e22

Symbol

BHLHE22 (may also be known as: None)

Organism

Human

Description

BHLHE22 belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. These proteins function as dimers and bind to an E-box DNA sequence (CANNTG). BHLHE22 is expressed exclusively in the central nervous system and retina (Xu et al., 2002 [PubMed 12213201]).[supplied by OMIM, Jul 2010]

Orthologs

Symbol	Species
Oli	Drosophila melanogaster
bhlhe22	Danio rerio
Bhlhe22	Mus musculus
Bhlhe22	Rattus norvegicus

Links to external resources

Entrez Gene: 27319
OMIM: 613483
Ensembl: ENSG00000180828
UniProt: Q8NFJ8
UniGene: Hs.388788
GeneCards

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA3798	Gene expression of BHLHE22 decreases with age	Molecular	skin	Human	BHLHE22	—

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GO Terms

GO ID	GO Term	GO Category
GO:0006355	regulation of transcription, DNA-dependent	biological_process
GO:0005634	nucleus	cellular_component