K(lysine) acetyltransferase 2A

Symbol

KAT2A (may also be known as: None)

Organism

Human

Description

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

Orthologs

SymbolSpecies
pcaf-1 Caenorhabditis elegans
kat2a Danio rerio
Kat2a Mus musculus
Kat2a Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3146 Gene expression of KAT2A increases with age Molecular skin Human KAT2A —

GO Terms

GO IDGO TermGO Category
GO:0001701 in utero embryonic development biological_process
GO:0001756 somitogenesis biological_process
GO:0001843 neural tube closure biological_process
GO:0006338 chromatin remodeling biological_process
GO:0006357 regulation of transcription from RNA polymerase II promoter biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0007399 nervous system development biological_process
GO:0008283 cell proliferation biological_process
GO:0016578 histone deubiquitination biological_process
GO:0021537 telencephalon development biological_process
GO:0022037 metencephalon development biological_process
GO:0030901 midbrain development biological_process
GO:0035264 multicellular organism growth biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0043966 histone H3 acetylation biological_process
GO:0044154 histone H3-K14 acetylation biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0005634 nucleus cellular_component
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex cellular_component
GO:0030914 STAGA complex cellular_component
GO:0033276 transcription factor TFTC complex cellular_component
GO:0003682 chromatin binding molecular_function
GO:0003713 transcription coactivator activity molecular_function
GO:0004402 histone acetyltransferase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0010484 H3 histone acetyltransferase activity molecular_function
GO:0016740 transferase activity molecular_function
GO:0042826 histone deacetylase binding molecular_function
GO:0043997 histone acetyltransferase activity (H4-K12 specific) molecular_function