synovial sarcoma translocation gene on chromosome 18-like 1

Symbol

SS18L1 (may also be known as: None)

Organism

Human

Description

Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L1 gene is homologous to SS18.[supplied by OMIM, Jul 2002]

Orthologs

SymbolSpecies
CELE_ZK973.9 Caenorhabditis elegans
Ss18l1 Mus musculus
Ss18l1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3774 Gene expression of SS18L1 increases with age Molecular skin Human SS18L1 —

GO Terms

GO IDGO TermGO Category
GO:0016358 dendrite development biological_process
GO:0016568 chromatin modification biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0000777 condensed chromosome kinetochore cellular_component
GO:0000780 condensed nuclear chromosome, centromeric region cellular_component
GO:0005634 nucleus cellular_component
GO:0005694 chromosome cellular_component