UPF2 regulator of nonsense transcripts homolog (yeast)
Symbol
UPF2
(may also be known as: None)
Organism
Human
Description
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]
Orthologs
Symbol | Species | |
---|---|---|
smg-3 | Caenorhabditis elegans | |
Upf2 | Drosophila melanogaster | |
upf2 | Danio rerio | |
Upf2 | Mus musculus | |
Upf2 | Rattus norvegicus | |
NMD2 | Saccharomyces cerevisiae | |
upf2 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | biological_process | |
GO:0006406 | mRNA export from nucleus | biological_process | |
GO:0010467 | gene expression | biological_process | |
GO:0016070 | RNA metabolic process | biological_process | |
GO:0016071 | mRNA metabolic process | biological_process | |
GO:0005634 | nucleus | cellular_component | |
GO:0005737 | cytoplasm | cellular_component | |
GO:0005829 | cytosol | cellular_component | |
GO:0035145 | exon-exon junction complex | cellular_component | |
GO:0048471 | perinuclear region of cytoplasm | cellular_component | |
GO:0003723 | RNA binding | molecular_function | |
GO:0005515 | protein binding | molecular_function | |