growth associated protein 43

Symbol

GAP43 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
gap43 Danio rerio
Gap43 Mus musculus
Gap43 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2800 Gene expression of GAP43 decreases with age Molecular adipose tissue Human GAP43 —
DAA3143 Gene expression of GAP43 decreases with age Molecular skin Human GAP43 —

GO Terms

GO IDGO TermGO Category
GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007399 nervous system development biological_process
GO:0009611 response to wounding biological_process
GO:0010001 glial cell differentiation biological_process
GO:0016198 axon choice point recognition biological_process
GO:0030154 cell differentiation biological_process
GO:0040008 regulation of growth biological_process
GO:0042246 tissue regeneration biological_process
GO:0045165 cell fate commitment biological_process
GO:0051489 regulation of filopodium assembly biological_process
GO:0005886 plasma membrane cellular_component
GO:0030054 cell junction cellular_component
GO:0030424 axon cellular_component
GO:0031527 filopodium membrane cellular_component
GO:0032584 growth cone membrane cellular_component
GO:0042995 cell projection cellular_component
GO:0045202 synapse cellular_component
GO:0005515 protein binding molecular_function
GO:0005516 calmodulin binding molecular_function