gamma-aminobutyric acid (GABA) A receptor, epsilon
Symbol
GABRE
(may also be known as: None)
Organism
Human
Description
The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Gabre | Mus musculus | |
| Gabre | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006810 | transport | biological_process | |
| GO:0006811 | ion transport | biological_process | |
| GO:0006821 | chloride transport | biological_process | |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0030054 | cell junction | cellular_component | |
| GO:0034707 | chloride channel complex | cellular_component | |
| GO:0045202 | synapse | cellular_component | |
| GO:0045211 | postsynaptic membrane | cellular_component | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0004890 | GABA-A receptor activity | molecular_function | |
| GO:0005216 | ion channel activity | molecular_function | |
| GO:0005230 | extracellular ligand-gated ion channel activity | molecular_function | |
| GO:0005254 | chloride channel activity | molecular_function | |