solute carrier family 37 (glucose-6-phosphate transporter), member 4

Symbol

SLC37A4 (may also be known as: None)

Organism

Human

Description

This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]

Orthologs

SymbolSpecies
hpo-12 Caenorhabditis elegans
slc37a4a Danio rerio
Slc37a4 Mus musculus
Slc37a4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3141 Gene expression of SLC37A4 increases with age Molecular skin Human SLC37A4 —

GO Terms

GO IDGO TermGO Category
GO:0005975 carbohydrate metabolic process biological_process
GO:0006006 glucose metabolic process biological_process
GO:0006810 transport biological_process
GO:0008643 carbohydrate transport biological_process
GO:0008645 hexose transport biological_process
GO:0015758 glucose transport biological_process
GO:0015760 glucose-6-phosphate transport biological_process
GO:0042593 glucose homeostasis biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0055085 transmembrane transport biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030176 integral to endoplasmic reticulum membrane cellular_component
GO:0005215 transporter activity molecular_function
GO:0015152 glucose-6-phosphate transmembrane transporter activity molecular_function