arachidonate 15-lipoxygenase, type B

Symbol

ALOX15B (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
si:dkey-17e16.9 Danio rerio
Alox15b Mus musculus
Alox15b Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2989 Gene expression of ALOX15B decreases with age Molecular skin Human ALOX15B —

GO Terms

GO IDGO TermGO Category
GO:0006629 lipid metabolic process biological_process
GO:0006631 fatty acid metabolic process biological_process
GO:0006917 induction of apoptosis biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0019370 leukotriene biosynthetic process biological_process
GO:0030336 negative regulation of cell migration biological_process
GO:0030850 prostate gland development biological_process
GO:0030856 regulation of epithelial cell differentiation biological_process
GO:0045786 negative regulation of cell cycle biological_process
GO:0045926 negative regulation of growth biological_process
GO:0005622 intracellular cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005506 iron ion binding molecular_function
GO:0016165 lipoxygenase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0050473 arachidonate 15-lipoxygenase activity molecular_function