arachidonate 5-lipoxygenase-activating protein
Symbol
ALOX5AP
(may also be known as: None)
Organism
Human
Description
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| alox5ap | Danio rerio | |
| Alox5ap | Mus musculus | |
| Alox5ap | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0002540 | leukotriene production involved in inflammatory response | biological_process | |
| GO:0019370 | leukotriene biosynthetic process | biological_process | |
| GO:0070207 | protein homotrimerization | biological_process | |
| GO:0071277 | cellular response to calcium ion | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005635 | nuclear envelope | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0005792 | microsome | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0031965 | nuclear membrane | cellular_component | |
| GO:0004051 | arachidonate 5-lipoxygenase activity | molecular_function | |
| GO:0004464 | leukotriene-C4 synthase activity | molecular_function | |
| GO:0004602 | glutathione peroxidase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008047 | enzyme activator activity | molecular_function | |
| GO:0019899 | enzyme binding | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |
| GO:0046982 | protein heterodimerization activity | molecular_function | |
| GO:0047485 | protein N-terminus binding | molecular_function | |
| GO:0050544 | arachidonic acid binding | molecular_function | |