phosphatidylinositol glycan anchor biosynthesis, class N
Symbol
PIGN
(may also be known as: None)
Organism
Human
Description
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is expressed in the endoplasmic reticulum and transfers phosphoethanolamine (EtNP) to the first mannose of the GPI anchor. Two alternatively spliced variants, which encode an identical isoform, have been reported. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CELE_Y54E10BR.1 | Caenorhabditis elegans | |
| CG2292 | Drosophila melanogaster | |
| pign | Danio rerio | |
| Pign | Mus musculus | |
| Pign | Rattus norvegicus | |
| MCD4 | Saccharomyces cerevisiae | |
| its8 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006501 | C-terminal protein lipidation | biological_process | |
| GO:0016254 | preassembly of GPI anchor in ER membrane | biological_process | |
| GO:0043687 | post-translational protein modification | biological_process | |
| GO:0044267 | cellular protein metabolic process | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0016740 | transferase activity | molecular_function | |