hes-related family bHLH transcription factor with YRPW motif 2

Symbol

HEY2 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
hey2 Danio rerio
Hey2 Mus musculus
Hey2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3732 Gene expression of HEY2 decreases with age Molecular skin Human HEY2 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001570 vasculogenesis biological_process
GO:0003171 atrioventricular valve development biological_process
GO:0003195 tricuspid valve formation biological_process
GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation biological_process
GO:0003208 cardiac ventricle morphogenesis biological_process
GO:0003222 ventricular trabecular myocardium morphogenesis biological_process
GO:0007219 Notch signaling pathway biological_process
GO:0007389 pattern specification process biological_process
GO:0009948 anterior/posterior axis specification biological_process
GO:0010460 positive regulation of heart rate biological_process
GO:0010621 negative regulation of transcription by transcription factor localization biological_process
GO:0010629 negative regulation of gene expression biological_process
GO:0010667 negative regulation of cardiac muscle cell apoptosis biological_process
GO:0014898 cardiac muscle hypertrophy in response to stress biological_process
GO:0045165 cell fate commitment biological_process
GO:0045607 regulation of auditory receptor cell differentiation biological_process
GO:0045746 negative regulation of Notch signaling pathway biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0051145 smooth muscle cell differentiation biological_process
GO:0055015 ventricular cardiac muscle cell development biological_process
GO:0060045 positive regulation of cardiac muscle cell proliferation biological_process
GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter biological_process
GO:0060840 artery development biological_process
GO:0060948 cardiac vascular smooth muscle cell development biological_process
GO:0060977 coronary vasculature morphogenesis biological_process
GO:0065004 protein-DNA complex assembly biological_process
GO:0090102 cochlea development biological_process
GO:0097084 vascular smooth muscle cell development biological_process
GO:2000678 negative regulation of transcription regulatory region DNA binding biological_process
GO:2000723 negative regulation of cardiac vascular smooth muscle cell differentiation biological_process
GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0016580 Sin3 complex cellular_component
GO:0017053 transcriptional repressor complex cellular_component
GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity molecular_function
GO:0000988 protein binding transcription factor activity molecular_function
GO:0001102 RNA polymerase II activating transcription factor binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0035939 microsatellite binding molecular_function
GO:0042826 histone deacetylase binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function