isoprenylcysteine carboxyl methyltransferase

Symbol

ICMT (may also be known as: None)

Organism

Human

Description

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
CELE_M01E11.1 Caenorhabditis elegans
ste14 Drosophila melanogaster
icmt Danio rerio
Icmt Mus musculus
Icmt Rattus norvegicus
STE14 Saccharomyces cerevisiae
mam4 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3729 Gene expression of ICMT decreases with age Molecular skin Human ICMT —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1562 isoprenylcysteine carboxyl methyltransferase Molecular lung Mouse Icmt 3.0% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0001701 in utero embryonic development biological_process
GO:0001889 liver development biological_process
GO:0006464 protein modification process biological_process
GO:0006481 C-terminal protein methylation biological_process
GO:0006612 protein targeting to membrane biological_process
GO:0008104 protein localization biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0035264 multicellular organism growth biological_process
GO:0046498 S-adenosylhomocysteine metabolic process biological_process
GO:0046499 S-adenosylmethioninamine metabolic process biological_process
GO:0046578 regulation of Ras protein signal transduction biological_process
GO:0005624 membrane fraction cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0003880 protein C-terminal carboxyl O-methyltransferase activity molecular_function
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity molecular_function
GO:0008140 cAMP response element binding protein binding molecular_function
GO:0008168 methyltransferase activity molecular_function
GO:0016740 transferase activity molecular_function