neuronal calcium sensor 1
Symbol
NCS1
(may also be known as: None)
Organism
Human
Description
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| ncs-1 | Caenorhabditis elegans | |
| Frq2 | Drosophila melanogaster | |
| ncs1b | Danio rerio | |
| Ncs1 | Mus musculus | |
| Ncs1 | Rattus norvegicus | |
| FRQ1 | Saccharomyces cerevisiae | |
| ncs1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0010975 | regulation of neuron projection development | biological_process | |
| GO:0045921 | positive regulation of exocytosis | biological_process | |
| GO:0048015 | phosphatidylinositol-mediated signaling | biological_process | |
| GO:0051927 | negative regulation of calcium ion transport via voltage-gated calcium channel activity | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0014069 | postsynaptic density | cellular_component | |
| GO:0030054 | cell junction | cellular_component | |
| GO:0030424 | axon | cellular_component | |
| GO:0030425 | dendrite | cellular_component | |
| GO:0031045 | dense core granule | cellular_component | |
| GO:0031410 | cytoplasmic vesicle | cellular_component | |
| GO:0032580 | Golgi cisterna membrane | cellular_component | |
| GO:0043231 | intracellular membrane-bounded organelle | cellular_component | |
| GO:0045202 | synapse | cellular_component | |
| GO:0045211 | postsynaptic membrane | cellular_component | |
| GO:0048471 | perinuclear region of cytoplasm | cellular_component | |
| GO:0005509 | calcium ion binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |