synemin, intermediate filament protein

Symbol

SYNM (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
synm Danio rerio
Synm Mus musculus
Synm Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3718 Gene expression of SYNM increases with age Molecular skin Human SYNM —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1327 synemin, intermediate filament protein Molecular hematological system Mouse Synm 66.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0045104 intermediate filament cytoskeleton organization biological_process
GO:0005624 membrane fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005882 intermediate filament cellular_component
GO:0005912 adherens junction cellular_component
GO:0030054 cell junction cellular_component
GO:0043034 costamere cellular_component
GO:0060053 neurofilament cytoskeleton cellular_component
GO:0005198 structural molecule activity molecular_function
GO:0005200 structural constituent of cytoskeleton molecular_function
GO:0005515 protein binding molecular_function
GO:0008307 structural constituent of muscle molecular_function
GO:0017166 vinculin binding molecular_function
GO:0019215 intermediate filament binding molecular_function