nuclear receptor coactivator 6

Symbol

NCOA6 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

Orthologs

SymbolSpecies
ncoa6 Danio rerio
Ncoa6 Mus musculus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3705 Gene expression of NCOA6 increases with age Molecular skin Human NCOA6 —

GO Terms

GO IDGO TermGO Category
GO:0006260 DNA replication biological_process
GO:0006281 DNA repair biological_process
GO:0006310 DNA recombination biological_process
GO:0006352 transcription initiation, DNA-dependent biological_process
GO:0006367 transcription initiation from RNA polymerase II promoter biological_process
GO:0007420 brain development biological_process
GO:0007507 heart development biological_process
GO:0009725 response to hormone stimulus biological_process
GO:0030099 myeloid cell differentiation biological_process
GO:0030520 intracellular estrogen receptor signaling pathway biological_process
GO:0042921 glucocorticoid receptor signaling pathway biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0060716 labyrinthine layer blood vessel development biological_process
GO:0005625 soluble fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0005730 nucleolus cellular_component
GO:0043231 intracellular membrane-bounded organelle cellular_component
GO:0003682 chromatin binding molecular_function
GO:0003713 transcription coactivator activity molecular_function
GO:0005515 protein binding molecular_function
GO:0016922 ligand-dependent nuclear receptor binding molecular_function
GO:0019899 enzyme binding molecular_function
GO:0030331 estrogen receptor binding molecular_function
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0046965 retinoid X receptor binding molecular_function
GO:0046966 thyroid hormone receptor binding molecular_function