spen family transcriptional repressor

Symbol

SPEN (may also be known as: None)

Organism

Human

Description

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
din-1 Caenorhabditis elegans
spen Drosophila melanogaster
spen Danio rerio
Spen Mus musculus
Spen Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3701 Gene expression of SPEN increases with age Molecular skin Human SPEN —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0007219 Notch signaling pathway biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0050769 positive regulation of neurogenesis biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0017053 transcriptional repressor complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0001085 RNA polymerase II transcription factor binding molecular_function
GO:0001191 RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription molecular_function
GO:0003676 nucleic acid binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003697 single-stranded DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003714 transcription corepressor activity molecular_function
GO:0003723 RNA binding molecular_function
GO:0005515 protein binding molecular_function