NLR family, pyrin domain containing 1
Symbol
NLRP1
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
Symbol | Species | |
---|---|---|
Nlrp1b | Mus musculus | |
Nlrp1b | Rattus norvegicus |
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA3681 | Gene expression of NLRP1 increases with age | Molecular | skin | Human | NLRP1 | — | |
DAA2249 | NLR family, pyrin domain containing 1 decreases with age | Molecular | frontal lobe | Human | NLRP1 | 29.4% Decrease Gene Expression Level | |
DAA2265 | NLR family, pyrin domain containing 1 decreases with age | Molecular | parietal lobe | Human | NLRP1 | 24.8% Decrease Gene Expression Level |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0006917 | induction of apoptosis | biological_process | |
GO:0006919 | activation of caspase activity | biological_process | |
GO:0006952 | defense response | biological_process | |
GO:0032495 | response to muramyl dipeptide | biological_process | |
GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | biological_process | |
GO:0042742 | defense response to bacterium | biological_process | |
GO:0042981 | regulation of apoptotic process | biological_process | |
GO:0045087 | innate immune response | biological_process | |
GO:0050718 | positive regulation of interleukin-1 beta secretion | biological_process | |
GO:0050727 | regulation of inflammatory response | biological_process | |
GO:0051402 | neuron apoptosis | biological_process | |
GO:0005622 | intracellular | cellular_component | |
GO:0005634 | nucleus | cellular_component | |
GO:0005737 | cytoplasm | cellular_component | |
GO:0005829 | cytosol | cellular_component | |
GO:0072558 | NLRP1 inflammasome complex | cellular_component | |
GO:0000166 | nucleotide binding | molecular_function | |
GO:0005515 | protein binding | molecular_function | |
GO:0005524 | ATP binding | molecular_function | |
GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process | molecular_function | |
GO:0019899 | enzyme binding | molecular_function | |
GO:0019904 | protein domain specific binding | molecular_function | |