dolichol kinase
Symbol
DOLK
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| CG8311 | Drosophila melanogaster | |
| dolk | Danio rerio | |
| Dolk | Mus musculus | |
| Dolk | Rattus norvegicus | |
| SEC59 | Saccharomyces cerevisiae | |
| sec59 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006488 | dolichol-linked oligosaccharide biosynthetic process | biological_process | |
| GO:0006489 | dolichyl diphosphate biosynthetic process | biological_process | |
| GO:0018279 | protein N-linked glycosylation via asparagine | biological_process | |
| GO:0043048 | dolichyl monophosphate biosynthetic process | biological_process | |
| GO:0043687 | post-translational protein modification | biological_process | |
| GO:0044267 | cellular protein metabolic process | biological_process | |
| GO:0005624 | membrane fraction | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0030176 | integral to endoplasmic reticulum membrane | cellular_component | |
| GO:0004168 | dolichol kinase activity | molecular_function | |
| GO:0016740 | transferase activity | molecular_function | |