unc-5 homolog B (C. elegans)

Symbol

UNC5B (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Orthologs

SymbolSpecies
unc5b Danio rerio
Unc5b Mus musculus
Unc5b Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4393 Gene expression of UNC5B decreases with age Molecular skin Human UNC5B —

GO Terms

GO IDGO TermGO Category
GO:0006915 apoptotic process biological_process
GO:0007165 signal transduction biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007411 axon guidance biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand biological_process
GO:0005886 plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0004872 receptor activity molecular_function
GO:0005042 netrin receptor activity molecular_function
GO:0005515 protein binding molecular_function