fibulin 1
Symbol
FBLN1
(may also be known as: None)
Organism
Human
Description
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| fbl-1 | Caenorhabditis elegans | |
| CG10323 | Drosophila melanogaster | |
| fbln1 | Danio rerio | |
| Fbln1 | Mus musculus | |
| Fbln1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007566 | embryo implantation | biological_process | |
| GO:0030198 | extracellular matrix organization | biological_process | |
| GO:0044419 | interspecies interaction between organisms | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005578 | proteinaceous extracellular matrix | cellular_component | |
| GO:0005604 | basement membrane | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005625 | soluble fraction | cellular_component | |
| GO:0031012 | extracellular matrix | cellular_component | |
| GO:0005201 | extracellular matrix structural constituent | molecular_function | |
| GO:0005509 | calcium ion binding | molecular_function | |
| GO:0016504 | peptidase activator activity | molecular_function | |