endoplasmic reticulum to nucleus signaling 1

Symbol

ERN1 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ern1 Danio rerio
Ern1 Mus musculus
Ern1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3123 Gene expression of ERN1 decreases with age Molecular skin Human ERN1 —

GO Terms

GO IDGO TermGO Category
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006397 mRNA processing biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006915 apoptotic process biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006986 response to unfolded protein biological_process
GO:0006987 activation of signaling protein activity involved in unfolded protein response biological_process
GO:0007050 cell cycle arrest biological_process
GO:0030968 endoplasmic reticulum unfolded protein response biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0005637 nuclear inner membrane cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030176 integral to endoplasmic reticulum membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0000287 magnesium ion binding molecular_function
GO:0004521 endoribonuclease activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters molecular_function