excision repair cross-complementation group 1

Symbol

ERCC1 (may also be known as: None)

Organism

Human

Description

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

Orthologs

SymbolSpecies
ercc-1 Caenorhabditis elegans
Ercc1 Drosophila melanogaster
ercc1 Danio rerio
Ercc1 Mus musculus
Ercc1 Rattus norvegicus
swi10 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3121 Gene expression of ERCC1 decreases with age Molecular skin Human ERCC1 —

GO Terms

GO IDGO TermGO Category
GO:0000718 nucleotide-excision repair, DNA damage removal biological_process
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair biological_process
GO:0001302 replicative cell aging biological_process
GO:0006281 DNA repair biological_process
GO:0006283 transcription-coupled nucleotide-excision repair biological_process
GO:0006289 nucleotide-excision repair biological_process
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion biological_process
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion biological_process
GO:0006302 double-strand break repair biological_process
GO:0006310 DNA recombination biological_process
GO:0006312 mitotic recombination biological_process
GO:0006949 syncytium formation biological_process
GO:0006979 response to oxidative stress biological_process
GO:0007281 germ cell development biological_process
GO:0007283 spermatogenesis biological_process
GO:0007584 response to nutrient biological_process
GO:0008283 cell proliferation biological_process
GO:0008584 male gonad development biological_process
GO:0009628 response to abiotic stimulus biological_process
GO:0009650 UV protection biological_process
GO:0009744 response to sucrose stimulus biological_process
GO:0010165 response to X-ray biological_process
GO:0010259 multicellular organismal aging biological_process
GO:0032205 negative regulation of telomere maintenance biological_process
GO:0035166 post-embryonic hemopoiesis biological_process
GO:0035264 multicellular organism growth biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0045190 isotype switching biological_process
GO:0048477 oogenesis biological_process
GO:0048568 embryonic organ development biological_process
GO:0051276 chromosome organization biological_process
GO:0000109 nucleotide-excision repair complex cellular_component
GO:0000784 nuclear chromosome, telomeric region cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0000014 single-stranded DNA specific endodeoxyribonuclease activity molecular_function
GO:0003684 damaged DNA binding molecular_function
GO:0003697 single-stranded DNA binding molecular_function
GO:0004519 endonuclease activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008022 protein C-terminus binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0019904 protein domain specific binding molecular_function
GO:0043566 structure-specific DNA binding molecular_function