EPH receptor B1

Symbol

EPHB1 (may also be known as: None)

Organism

Human

Description

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
si:ch211-234b19.1 Danio rerio
Ephb1 Mus musculus
Ephb1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3117 Gene expression of EPHB1 increases with age Molecular skin Human EPHB1 —

GO Terms

GO IDGO TermGO Category
GO:0001525 angiogenesis biological_process
GO:0006468 protein phosphorylation biological_process
GO:0007165 signal transduction biological_process
GO:0007411 axon guidance biological_process
GO:0021545 cranial nerve development biological_process
GO:0021631 optic nerve morphogenesis biological_process
GO:0021952 central nervous system projection neuron axonogenesis biological_process
GO:0022008 neurogenesis biological_process
GO:0030010 establishment of cell polarity biological_process
GO:0031290 retinal ganglion cell axon guidance biological_process
GO:0031589 cell-substrate adhesion biological_process
GO:0046328 regulation of JNK cascade biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0048013 ephrin receptor signaling pathway biological_process
GO:0048593 camera-type eye morphogenesis biological_process
GO:0050965 detection of temperature stimulus involved in sensory perception of pain biological_process
GO:0051965 positive regulation of synapse assembly biological_process
GO:0060326 cell chemotaxis biological_process
GO:0060996 dendritic spine development biological_process
GO:0060997 dendritic spine morphogenesis biological_process
GO:0061351 neural precursor cell proliferation biological_process
GO:0070372 regulation of ERK1 and ERK2 cascade biological_process
GO:0005737 cytoplasm cellular_component
GO:0005768 endosome cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030425 dendrite cellular_component
GO:0031901 early endosome membrane cellular_component
GO:0042995 cell projection cellular_component
GO:0045121 membrane raft cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0005003 ephrin receptor activity molecular_function
GO:0005005 transmembrane-ephrin receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008046 axon guidance receptor activity molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function