ephrin-A1

Symbol

EFNA1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
efna1b Danio rerio
Efna1 Mus musculus
Efna1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3112 Gene expression of EFNA1 increases with age Molecular skin Human EFNA1 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000187 activation of MAPK activity biological_process
GO:0003180 aortic valve morphogenesis biological_process
GO:0003183 mitral valve morphogenesis biological_process
GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation biological_process
GO:0007267 cell-cell signaling biological_process
GO:0010719 negative regulation of epithelial to mesenchymal transition biological_process
GO:0014028 notochord formation biological_process
GO:0016477 cell migration biological_process
GO:0030182 neuron differentiation biological_process
GO:0033628 regulation of cell adhesion mediated by integrin biological_process
GO:0034446 substrate adhesion-dependent cell spreading biological_process
GO:0043535 regulation of blood vessel endothelial cell migration biological_process
GO:0045765 regulation of angiogenesis biological_process
GO:0048013 ephrin receptor signaling pathway biological_process
GO:0050730 regulation of peptidyl-tyrosine phosphorylation biological_process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation biological_process
GO:0050770 regulation of axonogenesis biological_process
GO:0061002 negative regulation of dendritic spine morphogenesis biological_process
GO:0005576 extracellular region cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0046658 anchored to plasma membrane cellular_component
GO:0005102 receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0046875 ephrin receptor binding molecular_function