endothelin receptor type B

Symbol

EDNRB (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Orthologs

SymbolSpecies
ednrb1a Danio rerio
Ednrb Mus musculus
Ednrb Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3110 Gene expression of EDNRB decreases with age Molecular skin Human EDNRB —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001755 neural crest cell migration biological_process
GO:0006885 regulation of pH biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0007194 negative regulation of adenylate cyclase activity biological_process
GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger biological_process
GO:0007399 nervous system development biological_process
GO:0007422 peripheral nervous system development biological_process
GO:0007497 posterior midgut development biological_process
GO:0008217 regulation of blood pressure biological_process
GO:0014043 negative regulation of neuron maturation biological_process
GO:0014826 vein smooth muscle contraction biological_process
GO:0030318 melanocyte differentiation biological_process
GO:0032269 negative regulation of cellular protein metabolic process biological_process
GO:0035645 enteric smooth muscle cell differentiation biological_process
GO:0042310 vasoconstriction biological_process
GO:0048066 developmental pigmentation biological_process
GO:0048246 macrophage chemotaxis biological_process
GO:0048484 enteric nervous system development biological_process
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0004871 signal transducer activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004930 G-protein coupled receptor activity molecular_function
GO:0004962 endothelin receptor activity molecular_function
GO:0017046 peptide hormone binding molecular_function