solute carrier family 26 (anion exchanger), member 3
Symbol
SLC26A3
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Prestin | Drosophila melanogaster | |
| slc26a3 | Danio rerio | |
| Slc26a3 | Mus musculus | |
| Slc26a3 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0006811 | ion transport | biological_process | |
| GO:0006820 | anion transport | biological_process | |
| GO:0007588 | excretion | biological_process | |
| GO:0008272 | sulfate transport | biological_process | |
| GO:0034220 | ion transmembrane transport | biological_process | |
| GO:0055085 | transmembrane transport | biological_process | |
| GO:0005624 | membrane fraction | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0003712 | transcription cofactor activity | molecular_function | |
| GO:0005215 | transporter activity | molecular_function | |
| GO:0008271 | secondary active sulfate transmembrane transporter activity | molecular_function | |
| GO:0015297 | antiporter activity | molecular_function | |
| GO:0015301 | anion:anion antiporter activity | molecular_function | |