acyl-CoA wax alcohol acyltransferase 2
Symbol
AWAT2
(may also be known as: None)
Organism
Human
Description
This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| CG1941 | Drosophila melanogaster | |
| Awat2 | Mus musculus | |
| Awat2 | Rattus norvegicus | |
| DGA1 | Saccharomyces cerevisiae | |
| dga1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0008610 | lipid biosynthetic process | biological_process | |
| GO:0010025 | wax biosynthetic process | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0016747 | transferase activity, transferring acyl groups other than amino-acyl groups | molecular_function | |
| GO:0047196 | long-chain-alcohol O-fatty-acyltransferase activity | molecular_function | |