cytochrome P450, family 1, subfamily A, polypeptide 2

Symbol

CYP1A2 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
cyp1a Danio rerio
Cyp1a2 Mus musculus
Cyp1a2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3084 Gene expression of CYP1A2 decreases with age Molecular skin Human CYP1A2 —

GO Terms

GO IDGO TermGO Category
GO:0006706 steroid catabolic process biological_process
GO:0006725 cellular aromatic compound metabolic process biological_process
GO:0006778 porphyrin-containing compound metabolic process biological_process
GO:0006805 xenobiotic metabolic process biological_process
GO:0009403 toxin biosynthetic process biological_process
GO:0009791 post-embryonic development biological_process
GO:0009820 alkaloid metabolic process biological_process
GO:0010468 regulation of gene expression biological_process
GO:0016098 monoterpenoid metabolic process biological_process
GO:0017144 drug metabolic process biological_process
GO:0018894 dibenzo-p-dioxin metabolic process biological_process
GO:0030324 lung development biological_process
GO:0032259 methylation biological_process
GO:0032787 monocarboxylic acid metabolic process biological_process
GO:0042737 drug catabolic process biological_process
GO:0042738 exogenous drug catabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045333 cellular respiration biological_process
GO:0046483 heterocycle metabolic process biological_process
GO:0050665 hydrogen peroxide biosynthetic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0070989 oxidative demethylation biological_process
GO:0071615 oxidative deethylation biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0016020 membrane cellular_component
GO:0004497 monooxygenase activity molecular_function
GO:0009055 electron carrier activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen molecular_function
GO:0019899 enzyme binding molecular_function
GO:0020037 heme binding molecular_function
GO:0032451 demethylase activity molecular_function
GO:0034875 caffeine oxidase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0070330 aromatase activity molecular_function