cathepsin K
Symbol
CTSK
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| ctsk | Danio rerio | |
| Ctsk | Mus musculus | |
| Ctsk | Rattus norvegicus |
Links to external resources
Changes associated with this gene
Changes associated with the orthologs of this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA1290 | cathepsin K | Molecular | visual apparatus | Mouse | Ctsk | 58.0% Increase Gene Expression Level |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001957 | intramembranous ossification | biological_process | |
| GO:0006508 | proteolysis | biological_process | |
| GO:0045453 | bone resorption | biological_process | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005764 | lysosome | cellular_component | |
| GO:0004197 | cysteine-type endopeptidase activity | molecular_function | |
| GO:0008233 | peptidase activity | molecular_function | |
| GO:0008234 | cysteine-type peptidase activity | molecular_function | |