cathepsin G
Symbol
CTSG
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Ctsg | Mus musculus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006508 | proteolysis | biological_process | |
| GO:0006955 | immune response | biological_process | |
| GO:0032496 | response to lipopolysaccharide | biological_process | |
| GO:0044130 | negative regulation of growth of symbiont in host | biological_process | |
| GO:0050778 | positive regulation of immune response | biological_process | |
| GO:0050832 | defense response to fungus | biological_process | |
| GO:0070946 | neutrophil mediated killing of gram-positive bacterium | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0009986 | cell surface | cellular_component | |
| GO:0030141 | secretory granule | cellular_component | |
| GO:0031012 | extracellular matrix | cellular_component | |
| GO:0004252 | serine-type endopeptidase activity | molecular_function | |
| GO:0008201 | heparin binding | molecular_function | |
| GO:0008233 | peptidase activity | molecular_function | |