carnitine O-acetyltransferase
Symbol
CRAT
(may also be known as: None)
Organism
Human
Description
This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| CG5265 | Drosophila melanogaster | |
| zgc:154046 | Danio rerio | |
| Crat | Mus musculus | |
| Crat | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006631 | fatty acid metabolic process | biological_process | |
| GO:0006810 | transport | biological_process | |
| GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase | biological_process | |
| GO:0044255 | cellular lipid metabolic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005743 | mitochondrial inner membrane | cellular_component | |
| GO:0005777 | peroxisome | cellular_component | |
| GO:0005782 | peroxisomal matrix | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0004092 | carnitine O-acetyltransferase activity | molecular_function | |
| GO:0016740 | transferase activity | molecular_function | |
| GO:0016746 | transferase activity, transferring acyl groups | molecular_function | |