gamma-glutamyltransferase 6
Symbol
GGT6
(may also be known as: None)
Organism
Human
Description
GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Ggt6 | Mus musculus | |
| Ggt6 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006749 | glutathione metabolic process | biological_process | |
| GO:0006750 | glutathione biosynthetic process | biological_process | |
| GO:0019370 | leukotriene biosynthetic process | biological_process | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0031362 | anchored to external side of plasma membrane | cellular_component | |
| GO:0003840 | gamma-glutamyltransferase activity | molecular_function | |
| GO:0016746 | transferase activity, transferring acyl groups | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |