delta(4)-desaturase, sphingolipid 2
Symbol
DEGS2
(may also be known as: None)
Organism
Human
Description
This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| ifc | Drosophila melanogaster | |
| degs2 | Danio rerio | |
| Degs2 | Mus musculus | |
| Degs2 | Rattus norvegicus | |
| dsd1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006633 | fatty acid biosynthetic process | biological_process | |
| GO:0006665 | sphingolipid metabolic process | biological_process | |
| GO:0006667 | sphinganine metabolic process | biological_process | |
| GO:0030148 | sphingolipid biosynthetic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0046513 | ceramide biosynthetic process | biological_process | |
| GO:0055114 | oxidation-reduction process | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0000170 | sphingosine hydroxylase activity | molecular_function | |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | molecular_function | |
| GO:0042284 | sphingolipid delta-4 desaturase activity | molecular_function | |