serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Symbol
SERPINA3
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Serpina3b | Mus musculus | |
| uncharacterized_F1LV | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006953 | acute-phase response | biological_process | |
| GO:0006954 | inflammatory response | biological_process | |
| GO:0010951 | negative regulation of endopeptidase activity | biological_process | |
| GO:0019216 | regulation of lipid metabolic process | biological_process | |
| GO:0030162 | regulation of proteolysis | biological_process | |
| GO:0030277 | maintenance of gastrointestinal epithelium | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0004867 | serine-type endopeptidase inhibitor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0030414 | peptidase inhibitor activity | molecular_function | |