leucine zipper, putative tumor suppressor 1

Symbol

LZTS1 (may also be known as: None)

Organism

Human

Description

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]

Orthologs

SymbolSpecies
lzts1 Danio rerio
Lzts1 Mus musculus
Lzts1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3669 Gene expression of LZTS1 decreases with age Molecular skin Human LZTS1 —

GO Terms

GO IDGO TermGO Category
GO:0006351 transcription, DNA-dependent biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006383 transcription from RNA polymerase III promoter biological_process
GO:0006385 transcription elongation from RNA polymerase III promoter biological_process
GO:0006386 termination of RNA polymerase III transcription biological_process
GO:0007049 cell cycle biological_process
GO:0010467 gene expression biological_process
GO:0048814 regulation of dendrite morphogenesis biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0014069 postsynaptic density cellular_component
GO:0016324 apical plasma membrane cellular_component
GO:0030054 cell junction cellular_component
GO:0042995 cell projection cellular_component
GO:0043197 dendritic spine cellular_component
GO:0045202 synapse cellular_component
GO:0045211 postsynaptic membrane cellular_component
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0005515 protein binding molecular_function