WD repeat domain 5

Symbol

WDR5 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
wds Drosophila melanogaster
wdr5 Danio rerio
Wdr5 Mus musculus
Wdr5 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3664 Gene expression of WDR5 increases with age Molecular skin Human WDR5 —

GO Terms

GO IDGO TermGO Category
GO:0001501 skeletal system development biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0016568 chromatin modification biological_process
GO:0043966 histone H3 acetylation biological_process
GO:0043981 histone H4-K5 acetylation biological_process
GO:0043982 histone H4-K8 acetylation biological_process
GO:0043984 histone H4-K16 acetylation biological_process
GO:0051568 histone H3-K4 methylation biological_process
GO:0000123 histone acetyltransferase complex cellular_component
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex cellular_component
GO:0035097 histone methyltransferase complex cellular_component
GO:0048188 Set1C/COMPASS complex cellular_component
GO:0071339 MLL1 complex cellular_component
GO:0005515 protein binding molecular_function
GO:0042800 histone methyltransferase activity (H3-K4 specific) molecular_function
GO:0043995 histone acetyltransferase activity (H4-K5 specific) molecular_function
GO:0043996 histone acetyltransferase activity (H4-K8 specific) molecular_function
GO:0046972 histone acetyltransferase activity (H4-K16 specific) molecular_function