solute carrier family 27 (fatty acid transporter), member 2

Symbol

SLC27A2 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Orthologs

SymbolSpecies
slc27a2b Danio rerio
Slc27a2 Mus musculus
Slc27a2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3658 Gene expression of SLC27A2 decreases with age Molecular skin Human SLC27A2 —

GO Terms

GO IDGO TermGO Category
GO:0001561 fatty acid alpha-oxidation biological_process
GO:0006635 fatty acid beta-oxidation biological_process
GO:0006699 bile acid biosynthetic process biological_process
GO:0008206 bile acid metabolic process biological_process
GO:0042760 very long-chain fatty acid catabolic process biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0097089 methyl-branched fatty acid metabolic process biological_process
GO:0005739 mitochondrion cellular_component
GO:0005777 peroxisome cellular_component
GO:0005778 peroxisomal membrane cellular_component
GO:0005779 integral to peroxisomal membrane cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005788 endoplasmic reticulum lumen cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030176 integral to endoplasmic reticulum membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003824 catalytic activity molecular_function
GO:0004467 long-chain fatty acid-CoA ligase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0015245 fatty acid transporter activity molecular_function
GO:0016874 ligase activity molecular_function
GO:0031957 very long-chain fatty acid-CoA ligase activity molecular_function
GO:0050197 phytanate-CoA ligase activity molecular_function
GO:0070251 pristanate-CoA ligase activity molecular_function