NADPH oxidase activator 1

Symbol

NOXA1 (may also be known as: None)

Organism

Human

Description

This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Orthologs

SymbolSpecies
Noxa1 Mus musculus
Noxa1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3644 Gene expression of NOXA1 increases with age Molecular skin Human NOXA1 —

GO Terms

GO IDGO TermGO Category
GO:0006801 superoxide metabolic process biological_process
GO:0010310 regulation of hydrogen peroxide metabolic process biological_process
GO:0043085 positive regulation of catalytic activity biological_process
GO:0060263 regulation of respiratory burst biological_process
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0043020 NADPH oxidase complex cellular_component
GO:0005515 protein binding molecular_function
GO:0016176 superoxide-generating NADPH oxidase activator activity molecular_function
GO:0017124 SH3 domain binding molecular_function
GO:0019899 enzyme binding molecular_function
GO:0048365 Rac GTPase binding molecular_function