podoplanin

Symbol

PDPN (may also be known as: None)

Organism

Human

Description

This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Pdpn Mus musculus
Pdpn Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3632 Gene expression of PDPN decreases with age Molecular skin Human PDPN —

GO Terms

GO IDGO TermGO Category
GO:0000902 cell morphogenesis biological_process
GO:0001946 lymphangiogenesis biological_process
GO:0006693 prostaglandin metabolic process biological_process
GO:0006833 water transport biological_process
GO:0006865 amino acid transport biological_process
GO:0006954 inflammatory response biological_process
GO:0007049 cell cycle biological_process
GO:0007165 signal transduction biological_process
GO:0007399 nervous system development biological_process
GO:0008283 cell proliferation biological_process
GO:0008360 regulation of cell shape biological_process
GO:0009790 embryo development biological_process
GO:0010572 positive regulation of platelet activation biological_process
GO:0015884 folic acid transport biological_process
GO:0016337 cell-cell adhesion biological_process
GO:0030324 lung development biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0035239 tube morphogenesis biological_process
GO:0048286 lung alveolus development biological_process
GO:0051272 positive regulation of cellular component movement biological_process
GO:0055093 response to hyperoxia biological_process
GO:0001726 ruffle cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0016324 apical plasma membrane cellular_component
GO:0030027 lamellipodium cellular_component
GO:0030175 filopodium cellular_component
GO:0031258 lamellipodium membrane cellular_component
GO:0031527 filopodium membrane cellular_component
GO:0031528 microvillus membrane cellular_component
GO:0032587 ruffle membrane cellular_component
GO:0005372 water transmembrane transporter activity molecular_function
GO:0008517 folic acid transporter activity molecular_function
GO:0015171 amino acid transmembrane transporter activity molecular_function
GO:0015250 water channel activity molecular_function