leprecan-like 2
Symbol
LEPREL2
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| Leprel2 | Mus musculus | |
| Leprel2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0008285 | negative regulation of cell proliferation | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005488 | binding | molecular_function | |
| GO:0005506 | iron ion binding | molecular_function | |
| GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | molecular_function | |
| GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | molecular_function | |
| GO:0019797 | procollagen-proline 3-dioxygenase activity | molecular_function | |
| GO:0031418 | L-ascorbic acid binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |