MER proto-oncogene, tyrosine kinase

Symbol

MERTK (may also be known as: None)

Organism

Human

Description

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
mertk Danio rerio
Mertk Mus musculus
Mertk Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3617 Gene expression of MERTK decreases with age Molecular skin Human MERTK —

GO Terms

GO IDGO TermGO Category
GO:0001779 natural killer cell differentiation biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006909 phagocytosis biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0007267 cell-cell signaling biological_process
GO:0007283 spermatogenesis biological_process
GO:0007596 blood coagulation biological_process
GO:0030168 platelet activation biological_process
GO:0032940 secretion by cell biological_process
GO:0034446 substrate adhesion-dependent cell spreading biological_process
GO:0043277 apoptotic cell clearance biological_process
GO:0043491 protein kinase B signaling cascade biological_process
GO:0050900 leukocyte migration biological_process
GO:0051250 negative regulation of lymphocyte activation biological_process
GO:0060041 retina development in camera-type eye biological_process
GO:0060068 vagina development biological_process
GO:0001750 photoreceptor outer segment cellular_component
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0016028 rhabdomere cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0005524 ATP binding molecular_function