vav 3 guanine nucleotide exchange factor

Symbol

VAV3 (may also be known as: None)

Organism

Human

Description

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
vav3b Danio rerio
Vav3 Mus musculus
Vav3 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3616 Gene expression of VAV3 increases with age Molecular skin Human VAV3 —

GO Terms

GO IDGO TermGO Category
GO:0001525 angiogenesis biological_process
GO:0006906 vesicle fusion biological_process
GO:0006915 apoptotic process biological_process
GO:0006974 response to DNA damage stimulus biological_process
GO:0007229 integrin-mediated signaling pathway biological_process
GO:0007264 small GTPase mediated signal transduction biological_process
GO:0007596 blood coagulation biological_process
GO:0008624 induction of apoptosis by extracellular signals biological_process
GO:0016477 cell migration biological_process
GO:0030032 lamellipodium assembly biological_process
GO:0030168 platelet activation biological_process
GO:0030890 positive regulation of B cell proliferation biological_process
GO:0035023 regulation of Rho protein signal transduction biological_process
GO:0042493 response to drug biological_process
GO:0043087 regulation of GTPase activity biological_process
GO:0043547 positive regulation of GTPase activity biological_process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity biological_process
GO:0045785 positive regulation of cell adhesion biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0050790 regulation of catalytic activity biological_process
GO:0050853 B cell receptor signaling pathway biological_process
GO:0051056 regulation of small GTPase mediated signal transduction biological_process
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005070 SH3/SH2 adaptor activity molecular_function
GO:0005085 guanyl-nucleotide exchange factor activity molecular_function
GO:0005096 GTPase activator activity molecular_function
GO:0005154 epidermal growth factor receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0030676 Rac guanyl-nucleotide exchange factor activity molecular_function
GO:0046872 metal ion binding molecular_function