ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Symbol
ST3GAL6
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| St3gal6 | Mus musculus | |
| St3gal6 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006464 | protein modification process | biological_process | |
| GO:0006486 | protein glycosylation | biological_process | |
| GO:0006664 | glycolipid metabolic process | biological_process | |
| GO:0009311 | oligosaccharide metabolic process | biological_process | |
| GO:0071354 | cellular response to interleukin-6 | biological_process | |
| GO:0000139 | Golgi membrane | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0030173 | integral to Golgi membrane | cellular_component | |
| GO:0008373 | sialyltransferase activity | molecular_function | |
| GO:0052798 | beta-galactoside alpha-2,3-sialyltransferase activity | molecular_function | |