ubiquitination factor E4B

Symbol

UBE4B (may also be known as: None)

Organism

Human

Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ufd-2 Caenorhabditis elegans
CG9934 Drosophila melanogaster
ube4b Danio rerio
Ube4b Mus musculus
Ube4b Rattus norvegicus
UFD2 Saccharomyces cerevisiae
ufd2 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2090 ubiquitination factor E4B (UFD2 homolog, yeast) decreases with age Molecular ovary Human UBE4B 43.8% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000209 protein polyubiquitination biological_process
GO:0003222 ventricular trabecular myocardium morphogenesis biological_process
GO:0006915 apoptotic process biological_process
GO:0009411 response to UV biological_process
GO:0031175 neuron projection development biological_process
GO:0034976 response to endoplasmic reticulum stress biological_process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process
GO:0044257 cellular protein catabolic process biological_process
GO:0000151 ubiquitin ligase complex cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0019899 enzyme binding molecular_function
GO:0034450 ubiquitin-ubiquitin ligase activity molecular_function