cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Symbol

CDKN1A (may also be known as: P21, CIP1,)

Organism

Human

Orthologs

SymbolSpecies
cdkn1a Danio rerio
Cdkn1a Mus musculus
Cdkn1a Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA444 cyclin-dependent kinase inhibitor 1A (p21, Cip1) Molecular skeletal muscle Human CDKN1A 50.0% Increase Gene Expression Level
DAA3045 Gene expression of CDKN1A decreases with age Molecular skin Human CDKN1A —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1742 cyclin-dependent kinase inhibitor 1A (P21) Molecular muscle Mouse Cdkn1a 14.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000079 regulation of cyclin-dependent protein kinase activity biological_process
GO:0000080 G1 phase of mitotic cell cycle biological_process
GO:0000082 G1/S transition of mitotic cell cycle biological_process
GO:0000084 S phase of mitotic cell cycle biological_process
GO:0000086 G2/M transition of mitotic cell cycle biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0006974 response to DNA damage stimulus biological_process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest biological_process
GO:0007049 cell cycle biological_process
GO:0007050 cell cycle arrest biological_process
GO:0007265 Ras protein signal transduction biological_process
GO:0007346 regulation of mitotic cell cycle biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008629 induction of apoptosis by intracellular signals biological_process
GO:0009411 response to UV biological_process
GO:0009636 response to toxin biological_process
GO:0010243 response to organic nitrogen biological_process
GO:0010629 negative regulation of gene expression biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0016310 phosphorylation biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030890 positive regulation of B cell proliferation biological_process
GO:0031100 organ regeneration biological_process
GO:0031668 cellular response to extracellular stimulus biological_process
GO:0033158 regulation of protein import into nucleus, translocation biological_process
GO:0042326 negative regulation of phosphorylation biological_process
GO:0042493 response to drug biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043068 positive regulation of programmed cell death biological_process
GO:0045736 negative regulation of cyclin-dependent protein kinase activity biological_process
GO:0045768 positive regulation of anti-apoptosis biological_process
GO:0046685 response to arsenic-containing substance biological_process
GO:0048146 positive regulation of fibroblast proliferation biological_process
GO:0051412 response to corticosterone stimulus biological_process
GO:0055093 response to hyperoxia biological_process
GO:0071479 cellular response to ionizing radiation biological_process
GO:0090398 cellular senescence biological_process
GO:0090400 stress-induced premature senescence biological_process
GO:2000278 regulation of DNA biosynthetic process biological_process
GO:2000379 positive regulation of reactive oxygen species metabolic process biological_process
GO:0000307 cyclin-dependent protein kinase holoenzyme complex cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0070557 PCNA-p21 complex cellular_component
GO:0004693 cyclin-dependent protein kinase activity molecular_function
GO:0004860 protein kinase inhibitor activity molecular_function
GO:0004861 cyclin-dependent protein kinase inhibitor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0016301 kinase activity molecular_function
GO:0019912 cyclin-dependent protein kinase activating kinase activity molecular_function
GO:0030332 cyclin binding molecular_function
GO:0046872 metal ion binding molecular_function