dehydrogenase/reductase (SDR family) member 9

Symbol

DHRS9 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Orthologs

SymbolSpecies
dhs-2 Caenorhabditis elegans
Dhrs9 Mus musculus
Dhrs9 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3599 Gene expression of DHRS9 decreases with age Molecular skin Human DHRS9 —

GO Terms

GO IDGO TermGO Category
GO:0008209 androgen metabolic process biological_process
GO:0030855 epithelial cell differentiation biological_process
GO:0042448 progesterone metabolic process biological_process
GO:0042572 retinol metabolic process biological_process
GO:0042904 9-cis-retinoic acid biosynthetic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0016020 membrane cellular_component
GO:0030176 integral to endoplasmic reticulum membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004022 alcohol dehydrogenase (NAD) activity molecular_function
GO:0004745 retinol dehydrogenase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0016854 racemase and epimerase activity molecular_function
GO:0047035 testosterone dehydrogenase (NAD+) activity molecular_function