Epstein-Barr virus induced 3
Symbol
EBI3
(may also be known as: None)
Organism
Human
Description
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| ebi3 | Danio rerio | |
| Ebi3 | Mus musculus | |
| Ebi3 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2860 | Gene expression of EBI3 increases with age | Molecular | adipose tissue | Human | EBI3 | — |
Changes associated with the orthologs of this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA1306 | Epstein-Barr virus induced gene 3 | Molecular | hematological system | Mouse | Ebi3 | 27.0% Decrease Gene Expression Level |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006959 | humoral immune response | biological_process | |
| GO:0019221 | cytokine-mediated signaling pathway | biological_process | |
| GO:0042088 | T-helper 1 type immune response | biological_process | |
| GO:0045078 | positive regulation of interferon-gamma biosynthetic process | biological_process | |
| GO:0046641 | positive regulation of alpha-beta T cell proliferation | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0004896 | cytokine receptor activity | molecular_function | |
| GO:0005125 | cytokine activity | molecular_function | |
| GO:0045523 | interleukin-27 receptor binding | molecular_function | |