major histocompatibility complex, class I, E increases with age

Molecular

Process Measured

Gene Expression Level

Data Availability

20 to 99 years

Tissue

  • frontal lobe Changes

References

  • Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (PubMed)
Referencing provided by LibAge

Change

61.2% Increase in Gene Expression Level

Description

Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old)

Gene